High Purity L-5-Methyltetrahydrofolate Calcium/L-5-Mthf-Ca White Powder

• Powder: Yes
• Customized: Customized
• Certification: ISO 9001
• Suitable for: Elderly, Adult
• State: Solid
• Purity: >96%
• Model NO.: SH-P06
• Transport Package: Drum
• Specification: 1kg/Bag 25kg/Drum
• Trademark: Source Herb
• Origin: China
• Production Capacity: 500kg/Month

Product Description

L-5-Methyltetrahydrofolate calcium
 

L-5-Methyltetrahydrofolate calcium

Product	L-5-methyltetrahydrofolate Calcium		CAS NO:			151533-22-1
Executive Standard	SM-004(MC)-CP-04		Molecular Formula			C20H23CaN7O6
Packing	25kg/drum	Mfg. Date			2022.08.17
Batch No.	SH20220817	Exp. Date			2024.08.16
Quantity	3kg	Storage Conditions			shading, keep under seal
TEST ITEMS	STANDARD			RESULTS
Apprearance	White to light yellow crystalline powder			Conforms
SPECIFIC ROTATION (on anhydrous substance)	[a]^25D(C=1.5% in water)			+25.7°
IDENTIFICATION	HNMR should be identical with that of reference			Conforms
	major peak in the chromatograme of Assay preparation corresponds to that in the chromatograme of the standard preparation, as obtained in the Assay			Conforms
CALCIUM CONTENT (on anhydrous substance)	7.0% ~ 8.5%			7.49%
D-5-METHYLFOLATE	≤1.0%			0.18%
RELATED COMPOUNDS(HPLC)	Dimethyltetrahydrofolic acid≤0.15%			0.10%
	Single impurity≤1.0%			0.21%
	Total Impurites≤2.5%			1.02%
RESIDUAL SOLVENT	Ethanol NMT 5000ppm			240 ppm
WATER	≤16.0%			10.5%
CHLORIDE(Cl)	≤0.5%			Conforms
Assay	96.0% ~ 98.5%			98.85%
Heavy metals	NMT 10ppm			Complies
Arsenic (As)	NMT 2ppm			Complies
Cadmi um(Cd)	NMT 1ppm			Complies
Lead (Pb)	NMT 3ppm			Complies
Mer cury (Hg)	NMT 0.1ppm			Complies
Total Plate Count	1000cfu/g Max			Complies
Yeast & Mold	100cfu/g Max			Complies
Salmonella	Negative			Negative
E.Coli	Negative			Negative
Aflatoxins B1	<2ug/kg			Negative
Aflatoxins (B1,B2,G1,G2)	<4ug/kg			Negative
Conclusion: This product accords with the standard of Enterprise standard.

Product Introduction:
This product is a calcium salt of L-5-methyltetrahydrofolate, belonging to the folic acid group vitamin (vitamin B9, folic acid), which is a coenzyme form of folic acid. L-5-methyltetrahydrofolate calcium (5-mthChemicalbookf) is a naturally occurring salt forming methyl derivative form of folic acid. 5-mthf is also known as L-methylfolic acid, which is the most biologically active and functional form of folic acid and is more easily absorbed than ordinary folic acid.

Lack of folic acid can reduce the ability of cells to synthesize and repair DNA. Supplementing folic acid may be a more beneficial method to increase folic acid, reduce homocysteine levels, and support normal cell proliferation, vascular endothelial function. Cardiovascular disease, nervous system function, and especially 5-MTHF supplementation during pregnancy have been shown to reduce the risk of neural tube abnormalities and recurrence.

Metabolic Pathway

The only form of free folic acid present in human plasma and cells is 5-mthf. Folic acid deficiency is usually due to vitamin deficiency leading to insufficient absorption. During pregnancy, lactation, and child growth, the need for Chemicalbook folic acid is increased. Under the influence of absorption or metabolic changes or drugs, consuming folic acid rich foods cannot guarantee the dose provided, so supplementation is necessary.

Mechanism of action

The biochemical pathway of bioactive folic acid involves a series of enzymatic reactions and cofactors. The absorbed folic acid is reduced and methylated to 5-MTHF during the metabolism of intestinal mucosal cells. "This transition is limited and does not alter the presence of folic acid in the blood circulation, which is subsequently converted to s-adenosylmethionine (SAMe), and the methyl donor is involved in many biochemical processes.". It can also be used as a donor to participate in the synthesis of nucleotides and support biosynthetic DNA.

Biological activity

Levomefolatecacium is an artificial form of folic acid that resists the effects of folic acid.

SOURCEHERB Advantage:
Hangzhou Source Herb Biotechnology Co., Ltd. is a biotechnology company located in Hangzhou, China, focusing on the research and development of natural plant extracts and functional ingredients, providing plant extracts, natural pigments, plant proteins and other products and technical services.

The company's products are widely used in health products, food, cosmetics, medicine, agriculture and other fields. The company has a professional research and development team, as well as modern production equipment and laboratories. The company is committed to research and develop green, natural and healthy products, and actively promote the development of health industry.

Hangzhou Source Herb Biotechnology Co., Ltd. focuses on technical innovation and quality control, and has passed ISO22000 quality management system certification and HACCP food safety management system certification to ensure product quality and safety. At the same time, the company also actively participates in social public welfare undertakings and pays attention to environmental protection and sustainable development.

Product Function:
L-5-methyltetrahydrofolate (along with vitamin B12) plays a role as a methyl donor in a range of metabolic and nervous system processes, making it crucial for many metabolic pathways in the body. L-5-methyltetrahydrofolate plays a crucial role in methylation, converting homocysteine to methionine, producing serotonin and melatonin, and indirectly participating in DNA synthesis.

Studies have shown that neural tube defects in preterm women are associated with an increased risk of miscarriage. This is why it is now recommended to supplement folic acid before and during pregnancy, while increasing the intake of folic acid rich foods.

L-5-methyltetrahydrofolate is the strongest dietary folic acid. It is the only natural form of folate in our blood circulation, and therefore is a type of folate that is typically transported to peripheral tissue for cellular metabolism. Many people do not know that folic acid is a synthetic form of vitamins, which means it only exists in fortified foods and supplements. It is the most severely oxidized form of folic acid and does not possess the coenzyme activity required by the body. Therefore, it must be reduced and methylated in order to metabolize actively in the body. Within cells, folic acid is reduced to the metabolically active form of "tetrahydrofolate".

Packaging method:  MOQ:1KG/BAG  25KG/DRUM

Type of shipping: By DHL, FEDEX, By AIR , By SEA