Basic Info.
Suitable for
Elderly, Adult
Specification
1kg/Bag 25kg/Drum
Product Description
L-5-Methyltetrahydrofolate calcium
L-5-Methyltetrahydrofolate calcium| Product | L-5-methyltetrahydrofolate Calcium | CAS NO: | 151533-22-1 |
| Executive Standard | SM-004(MC)-CP-04 | Molecular Formula | C20H23CaN7O6 |
| Packing | 25kg/drum | Mfg. Date | 2022.08.17 |
| Batch No. | SH20220817 | Exp. Date | 2024.08.16 |
| Quantity | 3kg | Storage Conditions | shading, keep under seal |
| TEST ITEMS | STANDARD | RESULTS |
| Apprearance | White to light yellow crystalline powder | Conforms |
SPECIFIC ROTATION
(on anhydrous substance) | [a]25D(C=1.5% in water) | +25.7° |
| IDENTIFICATION | HNMR should be identical with that of reference | Conforms |
| major peak in the chromatograme of Assay preparation corresponds to that in the chromatograme of the standard preparation, as obtained in the Assay | Conforms |
CALCIUM CONTENT
(on anhydrous substance) | 7.0% ~ 8.5% | 7.49% |
| D-5-METHYLFOLATE | ≤1.0% | 0.18% |
| RELATED COMPOUNDS(HPLC) | Dimethyltetrahydrofolic acid≤0.15% | 0.10% |
| Single impurity≤1.0% | 0.21% |
| Total Impurites≤2.5% | 1.02% |
| RESIDUAL SOLVENT | Ethanol NMT 5000ppm | 240 ppm |
| WATER | ≤16.0% | 10.5% |
| CHLORIDE(Cl) | ≤0.5% | Conforms |
| Assay | 96.0% ~ 98.5% | 98.85% |
| Heavy metals | NMT 10ppm | Complies |
| Arsenic (As) | NMT 2ppm | Complies |
| Cadmi um(Cd) | NMT 1ppm | Complies |
| Lead (Pb) | NMT 3ppm | Complies |
| Mer cury (Hg) | NMT 0.1ppm | Complies |
| Total Plate Count | 1000cfu/g Max | Complies |
| Yeast & Mold | 100cfu/g Max | Complies |
| Salmonella | Negative | Negative |
| E.Coli | Negative | Negative |
| Aflatoxins B1 | <2ug/kg | Negative |
| Aflatoxins (B1,B2,G1,G2) | <4ug/kg | Negative |
| Conclusion: This product accords with the standard of Enterprise standard. |
This product is a calcium salt of L-5-methyltetrahydrofolate, belonging to the folic acid group vitamin (vitamin B9, folic acid), which is a coenzyme form of folic acid. L-5-methyltetrahydrofolate calcium (5-mthChemicalbookf) is a naturally occurring salt forming methyl derivative form of folic acid. 5-mthf is also known as L-methylfolic acid, which is the most biologically active and functional form of folic acid and is more easily absorbed than ordinary folic acid.
Lack of folic acid can reduce the ability of cells to synthesize and repair DNA. Supplementing folic acid may be a more beneficial method to increase folic acid, reduce homocysteine levels, and support normal cell proliferation, vascular endothelial function. Cardiovascular disease, nervous system function, and especially 5-MTHF supplementation during pregnancy have been shown to reduce the risk of neural tube abnormalities and recurrence.
Metabolic Pathway
The only form of free folic acid present in human plasma and cells is 5-mthf. Folic acid deficiency is usually due to vitamin deficiency leading to insufficient absorption. During pregnancy, lactation, and child growth, the need for Chemicalbook folic acid is increased. Under the influence of absorption or metabolic changes or drugs, consuming folic acid rich foods cannot guarantee the dose provided, so supplementation is necessary.
Mechanism of action
The biochemical pathway of bioactive folic acid involves a series of enzymatic reactions and cofactors. The absorbed folic acid is reduced and methylated to 5-MTHF during the metabolism of intestinal mucosal cells. "This transition is limited and does not alter the presence of folic acid in the blood circulation, which is subsequently converted to s-adenosylmethionine (SAMe), and the methyl donor is involved in many biochemical processes.". It can also be used as a donor to participate in the synthesis of nucleotides and support biosynthetic DNA.
Biological activity
Levomefolatecacium is an artificial form of folic acid that resists the effects of folic acid.
SOURCEHERB Advantage:
Hangzhou Source Herb Biotechnology Co., Ltd. is a biotechnology company located in Hangzhou, China, focusing on the research and development of natural plant extracts and functional ingredients, providing plant extracts, natural pigments, plant proteins and other products and technical services.
The company's products are widely used in health products, food, cosmetics, medicine, agriculture and other fields. The company has a professional research and development team, as well as modern production equipment and laboratories. The company is committed to research and develop green, natural and healthy products, and actively promote the development of health industry.
Hangzhou Source Herb Biotechnology Co., Ltd. focuses on technical innovation and quality control, and has passed ISO22000 quality management system certification and HACCP food safety management system certification to ensure product quality and safety. At the same time, the company also actively participates in social public welfare undertakings and pays attention to environmental protection and sustainable development.
Product Function:
L-5-methyltetrahydrofolate (along with vitamin B12) plays a role as a methyl donor in a range of metabolic and nervous system processes, making it crucial for many metabolic pathways in the body. L-5-methyltetrahydrofolate plays a crucial role in methylation, converting homocysteine to methionine, producing serotonin and melatonin, and indirectly participating in DNA synthesis.
Studies have shown that neural tube defects in preterm women are associated with an increased risk of miscarriage. This is why it is now recommended to supplement folic acid before and during pregnancy, while increasing the intake of folic acid rich foods.
L-5-methyltetrahydrofolate is the strongest dietary folic acid. It is the only natural form of folate in our blood circulation, and therefore is a type of folate that is typically transported to peripheral tissue for cellular metabolism. Many people do not know that folic acid is a synthetic form of vitamins, which means it only exists in fortified foods and supplements. It is the most severely oxidized form of folic acid and does not possess the coenzyme activity required by the body. Therefore, it must be reduced and methylated in order to metabolize actively in the body. Within cells, folic acid is reduced to the metabolically active form of "tetrahydrofolate".
Packaging method: MOQ:1KG/BAG 25KG/DRUM
Type of shipping: By DHL, FEDEX, By AIR , By SEA
Address:
Room 1-103, 2rd Building No. 16 Longtan Road, Cangqian Street, Hangzhou, Zhejiang, China
Business Type:
Trading Company
Business Range:
Chemicals, Health & Medicine
Management System Certification:
ISO 9001
Company Introduction:
Hangzhou Source Herb Biotechnology Co., Ltd was established in 2018 as a high-tech enterprise dedicated to the research, development, production, and sales of cosmetic raw materials, plant extracts, and raw materials of health care products.
Our company has a strong technical team that collaborates closely with the Fermentation Engineering Research Institute at Zhejiang University of Technology. Focused on research and technological innovation, the team develops new products while deepening the traditional product base. We are dedicated to product quality and safety. Due to reputation and persistence, our company′s products have gained a solid foothold in the domestic market and been exported to countries and regions such as Europe, US, Japan, and South Korea. Our company has become a renowned supplier to world-famous cosmetics and pharmaceutical enterprises.
We strive for superior quality and cost-effectiveness, always adhering to the principle of quality-oriented, honest operation. Our company is dedicated to creating mutually beneficial partnerships with both domestic and foreign enterprises and working together to create a better tomorrow.
