| Customization: | Available |
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| Packaging Material: | Paper |
| Storage Method: | Normal |
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Product Introduction:
Sodium cholate is a bile salt, which is a sodium salt of cholic acid. It is commonly used in biochemical research and has various applications in the medical and pharmaceutical fields.
Molecular Formula: C24H39NaO5
Molecular Weight: Approximately 430.55 g/mol
Appearance: White to off-white powder
Solubility: Soluble in water and ethanol
pH: Aqueous solutions of sodium cholate typically have a neutral to slightly alkaline pH.
Bile Acid: Sodium cholate plays a crucial role in the digestion and absorption of fats and fat-soluble vitamins in the small intestine. It acts as a detergent, emulsifying fats and aiding their breakdown by digestive enzymes.
Micelle Formation: In aqueous solutions, sodium cholate forms micelles, which are aggregates of molecules that can trap hydrophobic compounds, enhancing their solubility in water.
Biochemical Research:
Cell Membrane Studies: Sodium cholate is used to solubilize and study membrane proteins by breaking down lipid bilayers.
Enzyme Activity: It can stabilize enzymes in solution and is often used in assays to study enzyme functions.
Pharmaceuticals:
Drug Delivery: Sodium cholate is employed in drug formulations to improve the solubility and bioavailability of poorly water-soluble drugs.
Excipient: It serves as an excipient in various pharmaceutical formulations to enhance drug absorption.
Industrial Uses:
Detergents: Its surfactant properties make it useful in the formulation of certain detergents and cleaning agents.
Emulsifiers: Used in the food and cosmetic industries to stabilize emulsions.
Laboratory Reagent:
Protein Purification: It helps in the extraction and purification of proteins from biological samples.
Molecular Biology: Employed in various molecular biology protocols where solubilization of biological membranes is required.
1. Digestion and Absorption of Fats:
Emulsification: In the digestive system, sodium cholate acts as a detergent to emulsify dietary fats, breaking them into smaller micelles. This increases the surface area for the action of lipase enzymes, facilitating fat digestion.
Micelle Formation: It helps form micelles that encapsulate fatty acids, monoglycerides, and fat-soluble vitamins (A, D, E, K), making them more soluble in the aqueous environment of the intestine and aiding in their absorption.
2. Lipid Transport:
Sodium cholate assists in the transport of lipids from the intestine to the liver. The micelles formed by bile salts are absorbed by the intestinal lining and transported through the bloodstream to the liver for further processing.
Pharmaceutical and Medical Applications:
1.Drug Solubilization
Enhanced Bioavailability: Sodium cholate is used to enhance the solubility and bioavailability of poorly water-soluble drugs. By forming micelles, it can encapsulate hydrophobic drug molecules, making them more soluble and absorbable in the gastrointestinal tract.
2. Drug Delivery Systems
Carrier: It serves as a carrier in drug delivery systems, helping to deliver drugs more effectively to their target sites. It can improve the stability and controlled release of drugs.
3.Excipient in Formulations:
Stabilizer: Used as an excipient in pharmaceutical formulations, sodium cholate can stabilize active ingredients, ensuring their efficacy over time.
1. Membrane Protein Solubilization:
Detergent: Sodium cholate is commonly used as a detergent to solubilize membrane proteins from cell membranes. This allows researchers to isolate and study these proteins in a more controlled environment.
Non-denaturing Properties: Unlike harsher detergents, sodium cholate can solubilize proteins without denaturing them, preserving their functional and structural integrity.
2. Protein Purification:
Lysing Cells: It is used to lyse cells and extract proteins for purification and analysis. This is essential in research involving protein structure and function.
Affinity Chromatography: Sodium cholate can be used in various chromatography techniques to purify specific proteins or biomolecules based on their affinity for the bile salt.
Industrial Applications:
1. Surfactant:
Emulsification: In the food and cosmetic industries, sodium cholate serves as an emulsifying agent, helping to mix ingredients that typically do not blend well, such as oil and water.
Cleaning Agents: Due to its surfactant properties, it is also used in some cleaning and detergent formulations to enhance their effectiveness.
Packaging Method: MOQ:1KG/BAG 25KG/DRUM
Type of Shipping: By DHL, FEDEX, By AIR , By SEA
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