Supply High Quality Valinomycin CAS No 2001-95-8 For Anti Bacterium
Product Description:
Valinomycin (CAS No. 2001-95-8) is a cyclic peptide composed of 12 amino acids, characterized by its lipid-soluble antibiotic properties. It selectively binds to potassium ions (K+), significantly enhancing their transmembrane diffusion rate by up to 100,000 times.
Its unique molecular structure makes it an excellent chiral stationary phase for gas chromatography, liquid chromatography, and capillary electrophoresis. In the biomedical field, valinomycin has diverse applications, including inducing apoptosis, inhibiting oxidative phosphorylation, and preventing neuronal differentiation, as well as counteracting endothelin-induced vasoconstriction.
Additionally, it serves as an insecticidal antibiotic in agriculture, with potential uses as an insecticide or plant growth regulator. In analytical chemistry, valinomycin is utilized to create sensing membranes for potassium ion-selective electrodes, enabling highly sensitive potassium detection. Overall, valinomycin's multifunctional properties and broad application prospects make it an ideal choice for research and application across various fields.
Product Function:
Ionophore: Valinomycin acts as an ionophore specifically for potassium ions (K). It binds to potassium ions and transports them through lipid membranes, facilitating their movement across cell membranes.
Transport Mechanism: It forms complexes with K ions, enabling their movement down the electrochemical gradient across biological membranes.
Product Application:
Research Tool: Valinomycin is primarily used as a research tool in biochemistry and cell biology to study the transport of potassium ions across membranes. It helps in understanding ion transport mechanisms and membrane potential.
Medicinal Potential: There has been exploration into its potential medical applications, particularly in antimicrobial and antitumor activities. However, its clinical use is limited due to toxicity concerns and the availability of more specific drugs for targeted applications.
Ion Selectivity Studies: Because of its specificity for potassium ions, valinomycin is used to study potassium ion channels and receptors, aiding in pharmacological and physiological studies.
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