Factory Supply High Quality API Intermediate 7-Ethyl-10-Hydroxycamptothecin CAS 86639-52-3

• Customization: Available
• Certification: FDA, HACCP
• Assay Method: HPLC, UV
• Model NO.: 7-Ethyl-10-hydroxycamptothecin
• Application: Medicine
• State: Powder
• Extract Source: Chemical
• Transport Package: Bag/Drum
• Specification: 25KG/Drum, 1KG/Bag
• Trademark: Source herb
• Origin: China
• Production Capacity: 10000kg/Year

Product Description

API Intermediate 7-Ethyl-10-hydroxycamptothecin CAS 86639-52-3

Product Description:

Product Name	7-Ethyl-10-hydroxycamptothecin
CAS No.	86639-52-3
Appearance	Off white powder

7-Ethyl-10-Hydroxycamptothecin is a light yellow crystalline powder with a melting point of 230 ºC to 237 ºC.
SN-38 (NK012) is an active metabolite of CPT-11, which inhibits DNA topoisomerase I, DNA synthesis, and causes frequent DNA single strand breaks. SN-38 can induce autophagy.
SN-38 is a bioactive metabolite of irinotecan hydrochloride (CPT-11). SN-38 causes the strongest inhibition of DNA topoisomerase I, followed by CPT, and then CPT-11. CPT-11 dose dependently transfers the position of loose DNA in the direction of the DNA incision, but SN-38 and CPT have no effect on the position of loose DNA. SN-38 inhibits DNA synthesis in a dose-dependent and time-dependent manner. The IC50 values of SN-38 are 0.077 micrometers in DNA synthesis. The inhibitory effect of SN-38 on cellular RNA synthesis is smaller than that on DNA synthesis and it does not inhibit protein synthesis. SN-38 causes frequent DNA single strand breaks in P388 cells.
After oral administration, the highest concentration of SN-38 appeared 1 hour later, and the percentage of unbound SN-38 lactone in mouse plasma was 3.4+/-0.67% at 1000 ng/mL, while the percentage of unbound at 100 ng/mL was 1.18+/-0.14%. The AUC of SN-38 lactone in nude mice containing human neuroblastoma is greater than that in non tumor animals.

Application:
1. Used for preparing irinotecan hydrochloride;
2. The active metabolite of irinotecan is topoisomerase I inhibitor, with IC50 values of 0.077 and 1.3 μ M, respectively, for inhibiting DNA synthesis and RNA synthesis.

FAQ:

1. What's the MOQ?

Generally the MOQ is 1kg, Best 25KG/DRUM

1. Is there any discount?

Yes, we will give you the best discount according to the size of your order!

1. How can I confirm the product quality before placing orders?

We will send you the existing sample or prepare the sample according to your request and send it to you for your confirmation!

1. How do you treat quality complaint?

If the quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately!

1. How to contact with us ?

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1. How to place an order & payment ?

(1). Conduct product consultation,
(2). Determine the sample,
(3).After the sample quality meets the requirements, send us the PO,
(4). We reply to PI
(5). The customer completes the payment,
(6). Receive payment for goods, export products,
(7). The customer receives the goods and completes the order.

Cooperative customers:
Our products are exported to European and American countries.
It also has a large customer base in Southeast Asia and other regions.

After-sale service:
If the quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately!
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