Factory Supply High Quality API Irinotecan Hydrochloride CAS 100286-90-6

• Customization: Available
• Certification: FDA, HACCP
• Assay Method: HPLC, UV
• Model NO.: Irinotecan Hydrochloride
• Application Form: Tablet, Capsule
• Application: Medicine
• State: Powder
• Extract Source: Chemical
• Transport Package: Bag/Drum
• Specification: 25KG/Drum, 1KG/Bag
• Trademark: Source herb
• Origin: China
• Production Capacity: 10000kg/Year

Product Description

API Irinotecan Hydrochloride CAS 100286-90-6

Product Description:

Product Name	Irinotecan hydrochloride
CAS No.	100286-90-6
Appearance	Light yellow crystalline powder

Irinotecan hydrochloride is a semi synthetic water-soluble derivative of camptothecin, which is a light yellow powder or light yellow crystalline powder at room temperature and odorless. Slightly soluble in water, ethanol, or chloroform, insoluble in acetone. Camptothecin can specifically bind to topoisomerase I, which induces reversible single strand breaks, thereby unwinding the DNA double stranded structure; Irinotecan and its active metabolite SN-38 can bind to topoisomerase I-DNA complex, thereby preventing the reconnection of broken single bonds, resulting in cytotoxicity. This cytotoxicity is time-dependent and specifically acts on the S phase, with stronger toxicity than Irinotecan. Suitable for the treatment of advanced colorectal cancer patients, combined with 5-fluorouracil and folinic acid for the treatment of advanced colorectal cancer patients who have not received chemotherapy before. As a monotherapy, it is used to treat patients who have failed to receive chemotherapy containing 5-fluorouracil. Irinotecan has broad-spectrum and strong anti-tumor activity in both in vivo and in vitro studies. Importantly, Irinotecan and its metabolites remain effective against tumors expressing multidrug resistance.

Irinotecan hydrochloride ((+) - Irinotecan hydrochloride) is a topoisomerase I inhibitor that can be used in the study of colon and rectal cancer.

Irinotecan hydrochloride is a topoisomerase I inhibitor. Irinotecan inhibits the growth of LoVo and HT-29 cells, with IC ₅₀ s of 15.8 ± 5.1 and 5.17 ± 1.4 μM, respectively, and induces similar amounts of cleavable complexes in both in LoVo and HT-29 cells. Irinotecan suppresses the proliferation of human umbilical vein endothelial cells (HUVEC), with an IC ₅₀ of 1.3 μM.

Irinotecan (CPT-11, 5 mg/kg) significantly inhibits the growth of tumors by intratumoral injection daily for 5 days, on two consecutive weeks in rats, and such effects also occur via continuous intraperitoneal infusion by osmotic minipump into mice. However, Irinotecan (10 mg/kg) shows no effect on the growth of tumor by i.p. Irinotecan (CPT-11, 100-300 mg/kg, i.p.) apparently suppresses tumor growth of HT-29 xenografts in athymic female mice by day 21. The two groups of Irinotecan (125 mg/kg) plus TSP-1 (10 mg/kg per day) or Irinotecan (150 mg/kg) in combination TSP-1 (20 mg/kg per day) are nearly equally effective and inhibit tumor growth 84% and 89%, respectively, and both are more effective than Irinotecan alone at doses of 250 and 300 mg/kg.

Appearance:
1. Used for preparing injections;
2. Used as an anti-tumor drug;
3. As an intermediate for steroid hormone drugs;
4. A water-soluble topoisomerase I inhibitor.

FAQ:

1. What's the MOQ?

Generally the MOQ is 1kg, Best 25KG/DRUM

1. Is there any discount?

Yes, we will give you the best discount according to the size of your order!

1. How can I confirm the product quality before placing orders?

We will send you the existing sample or prepare the sample according to your request and send it to you for your confirmation!

1. How do you treat quality complaint?

If the quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately!

1. How to contact with us ?

Through SKYPE, WHATSAPP, WeChat, and E-mail.

1. How to place an order & payment ?

(1). Conduct product consultation,
(2). Determine the sample,
(3).After the sample quality meets the requirements, send us the PO,
(4). We reply to PI
(5). The customer completes the payment,
(6). Receive payment for goods, export products,
(7). The customer receives the goods and completes the order.

Cooperative customers:
Our products are exported to European and American countries.
It also has a large customer base in Southeast Asia and other regions.

After-sale service:
If the quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately!
100% responsible person, safe and reliable, integrity first.