Product Instruction:
Ethyl caffeite is a chemical substance with the molecular formula C11H12O4 and a molecular weight of 208.21.
Ethyl Caffeite is a natural phenolic compound isolated from Bidens pilosa. Ethyl Caffeite inhibits NF in vitro or in mouse NF- κ B activation and its downstream inflammatory mediators, inducible nitric-oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2).
Pharmacological mechanism:
The molecular mechanism by which caffeic acid ethyl ester inhibits lymphocyte activation lays the foundation for the development of new drugs for treating autoimmune diseases.
The CCK-8 method and ELISA method were used to determine the effects of caffeic acid ethyl ester on mitogen induced proliferation of splenic lymphocytes and the production levels of cytokines (IL-2, IFN -, and IL-6). An antigen specific immune response induced by ovalbumin was established to detect the effects of in vivo administration of caffeic acid ethyl ester on cell activation and cytokine (IL-2, IFN -) secretion levels; Real time fluorescence quantitative detection of the expression of cytokines (IL-2, IFN -) and related transcription factors (T-BET and SAT1); Measurement and signal transduction of signaling pathways (and phosphorylation levels). Results: Caffeic acid ethyl ester significantly inhibited the induced proliferation of normal mouse spleen lymphocytes and the production of cytokines (IL-2, and). Oral administration of caffeic acid ethyl ester significantly inhibited the induced antigen-specific cell proliferation and cytokine production levels. At the transcriptional level, it significantly inhibited the expression levels of IL-2, IFN -, T-BET, and SAT1m-RNA.
Caffeic acid ethyl ester can effectively inhibit and signal mediate the MAPK signaling pathway (TCR/CD3 and CD28), with the most significant inhibition on P38.
Conclusion: Ethyl caffeic acid, an effective component of Dixiacao, may intervene in the IL-2, IFN -, T-BET, and SAT1 signaling pathways by inhibiting phosphorylation of the MAPK signaling pathway (P38 and ERKI/2), downregulating transcription factors and expressing BET and SAT1 signals, inhibiting production and cell activation.
Packaging method: MOQ:1KG/BAG 25KG/DRUM
Type of shipping:By DHL, FEDEX, By AIR , By SEA
FAQ: 1.What's the MOQ? Generally the MOQ is 1kg, Best 25KG/DRUM 2.Is there any discount? Yes, we will give you the best discount according to the size of your order! 3.How can I confirm the product quality before placing orders? We will send you the existing sample or prepare the sample according to your request and send it to you for your confirmation! 4.How do you treat quality complaint? If the quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately!
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Cooperative customers: Our products are exported to European and American countries. It also has a large customer base in Southeast Asia and other regions.
After-sale service: If the quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately!
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