Factory Supply High Quality 99% O-Phospho-L-Serine CAS 407-41-0

• Customization: Available
• CAS No.: 407-41-0
• Formula: C3h8no6p
• Model NO.: O-Phospho-L-serine
• Packaging Material: Sealed Bag
• Storage Method: No Light
• Shelf Life: 2 Years
• Nutrient Composition: Amino Acid
• Resource: Chemosynthesis
• The content of active substances: ＞90%
• Transport Package: 25kg/Drum
• Specification: 25KG/Drum, 1KG/Bag
• Trademark: Source herb
• Origin: China
• Production Capacity: 10000kg/Year

Product Description

O-Phospho-L-serine

Product Information:

Product Name:	O-Phospho-L-serine
CAS NO.:	407-41-0
Molecular Formula:	C3H8NO6P
Molecular Weight:	185.07
Purity:	More Than 99%
Appearance:	White powder

O-Phospho-L-serine is a direct precursor substance in the synthesis of L-serine and is an agonist of the third group of mGluRs (mGluR4, mGluR6, mGluR7, and mGluR8). O-Phospho-L-serine is also an antagonist of mGluR1 and mGluR2.

Applications:
O-Phospho-L-serine (l-SOP) weakly binds to mGluR1, and antagonizes the effects of l-glutamate. l-SOP activates the group III receptors (mGluR4, mGluR6, mGluR7, and mGluR8), but mGluR7 has much lower affinity for l-SOP than the other group III receptors and also displays lower efficacy for both ligands. O-Phospho-L-serine (l-SOP) generates enhanced intracellular calcium responses in mGluR4 transfected cells. l-SOP inhibits the l-glutamate mediated mGluR1 response, with a K _i of 1 mM; l-SOP displays a substantially more potent inhibition of mGluR2 activation, with a K _i of 1 μM, three orders-of-magnitude more potent than for mGluR1. l-SOP induces membrane potential changes in HEK/TRPC4 cells transfected with mGluR4 or mGluR6. l-SOP induces TRPC4β activation mediated by Gα _i/o proteins. O-Phospho-L-serine (L-SOP) inhibits Müller glia proliferation, without affecting light-induced photoreceptor cell death. L-SOP disrupts Müller glia proliferation subsequent to or in parallel with the activation of ascl1a and stat3 expression in the light-damaged retina. L-SOP inhibits cone cell regeneration in the light-damaged retina.